Sociando a écrit :
Le must, c'est la prise d'ATB qui supprime la réponse anticorps mais laisse l'infection !!!!!!!
Depuis quand les ATB ont une action directe sur la production d'anticorps !!!!
Soc
"depuis quand???" dis-tu?
ben, depuis toujours...
et on le sait depuis belle lurette...
un peu de lecture:
(évidemment, en espérant que, contrairement à un certain prof C. de strasbourg,
tu saches lire l'anglais.)
si t'as des difficultés avec l'anglais...
ben... pas étonnant que tu sois à la ramasse, niveau information et actualisation de tes connaissances.
http://www.aafp.org/afp/2005/0715/p297.html
False-negative results often are attributable to tests taken too early in the course of infection. Because the antibody response develops slowly, tests taken within the first two weeks of infection have low sensitivities (less than 50 percent). Antibiotics also can influence the results of serologic tests when given early in the course of infection, and have been shown to abort seroconversion, even if inadequate therapy is provided.
http://www.fpnotebook.com/ID/Lab/LymTtr.htm
Causes of Lyme serology false negatives
1. Testing within first 2 weeks of symptoms
2. Antibiotics early in course of lyme infection
1. Inadequate antibiotic course can blunt seroconversion
http://www.avonhistory.org/bug/l9.htm
If treated with antibiotics early in the course of the infection, such as within the first week, the entire antibody response may be aborted and a positive blood test may never develop.
http://www.aldf.com/pdf/Porwancher_Diag ... ersion.pdf
Given the significant fraction of patients with false-negative tests during the early phase of the illness, a negative result is not reliable and therefore a physician must use their best clinical judgment concerning treatment. This caveat concerning early diagnosis should not be applied to late disease, where over 95% of sera are positive using the two-step method (15). On occasion patients with early neurological disease (e.g. facial palsy and aseptic meningitis) may become negative by the two-step method following antibiotic treatment (16)
http://www.dhh.louisiana.gov/offices/mi ... Manual.pdf
The following may be found in Lyme disease serology testing:
- False negative serologic tests during acute disease
- False negative due to early antibiotic treatment
http://www.lumrix.net/health/Lyme_disea ... versy.html
# False negative test results due to the following, particularly in late and chronic Lyme disease:Immune system evasion by Borrelia burgdorferi.
Intracellular sequestration, antigen variation, immune suppression, the formation of immune complexes, and predominance of cystic forms have all been cited as reasons for seronegativity in late and chronic Lyme disease
... donc si tu changeais de métier???
tu te ridiculises en t'esclaffant sur le fait que les antibios répriment une séroconversion
tu es dans l'ignorance de faits reconnus de par le monde... (même par les pro-CDC)
et viens l'étaler ici...
pas malin de ta part...
ensuite, voici une liste de 53 articles sur la séronégativité et les faux-négatifs en sérologie.
malgré des manifestations (tardives) d'une borréliose, démontrée par d'autres procédés que la sérologie.
http://www.lymeinfo.net/medical/LDSeronegativity.pdf
(aller à "seronegativity")
comme tu ne vas pas tout lire, parmi cette liste, je t'ai choisi juste les articles dont les titres parlent d'eux-mêmes
Dejmkova H, Hulinska D, Tegzova D, Pavelka K, Gatterova J, Vavrik P.
Seronegative arthritis caused by Borrelia garinii.
Tylewska-Wierzbanowska S, Chmielewski T.
Limitation of serologic testing for Lyme borreliosis: evaluation of ELISA and western blot in comparison with PCR and culture methods.
Brunner M.
New method for detection of Borrelia burgdorferi antigen complexed to antibody in seronegative Lyme disease.
Paul A.
Arthritis, headache, facial paralysis. Despite negative laboratory tests Borrelia can still be the cause.
Breier F, Khanakah G, Stanek G, Kunz G, Aberer E, et al.
Isolation and polymerase chain reaction typing of Borrelia afzeii from a skin lesion in a seronegative patient with generalized ulcerating bullous lichen sclerosus et atrophicus.
Brunner M, Sigal LH.
Immune complexes from serum of patients with Lyme disease contain Borrelia burgdorferi antigen and antigen-specific antibodies: potential use for improved testing.
Kaiser R.
False-negative serology in patients with neuroborreliosis and the value of employing of different borrelial strains in serological assays.
Schumacher HR.
PCR evidence for Borrelia burgdorferi DNA in synovium in absence of positive serology.
Branigan P, Rao J, Gerard H, Hudson A, Williams W, Arayssi T, et al.
PCR evidence for Borrelia burgdorferi DNA in synovium in absence of positive serology.
Coyle PK, Schutzer SE, Deng Z, Krupp LB, Belman MD, Benach JL, et al.
Detection of Borrelia burgdorferi-specific antigen in antibody negative cerebrospinal fluid in neurologic Lyme disease.
Lawrence C, Lipton RB, Lowy FD, Coyle PK.
Seronegative chronic relapsing neuroborreliosis.
Schubert HD, Greenebaum E, Neu HC.
Cytologically proven seronegative Lyme choroiditis and vitritis.
Steere AC.
Seronegative Lyme disease.
Havlik J, Rohacova H, Hulinska D, et al.
Seronegative Lyme borreliosis.
Nields JA, Kueton JF.
Tullio phenomenon and seronegative Lyme borreliosis.
Schutzer SE, Coyle PK, Belman AL, Golightly MG, Drulle J.
Sequestration of antibody to Borrelia burgdorferi in immune complexes in seronegative Lyme disease.
Guy EC, Turner AM.
Seronegative neuroborreliosis.
Dattwyler RJ, Volkman DJ, Luft BJ, Halperin JJ, Thomas J, Golightly MG.
Seronegative Lyme disease. Dissociation of specific T- and B-lymphocyte responses to Borrelia burgdorferi.
voilà, ce n'est qu'une fraction des articles retrouvés qui constatent les échecs de la sérologie.
en rouge, tu noteras une attention toute particulière aux
complexes immuns qui te font aussi te tordre de rire, apparemment...
encore une fois: pas très malin...