lyme et SEP en république Tchèque
Posté : 30 mars 2006 12:12
Borreliosis is caused by the tick-borne spirochete
Borrelia burgdorferi. The spirochetes may invade
different organs including the nervous system,
heart, joints and skin. Involvement of the
nervous system called neuroborreliosis (NB) is
an inflammatory disease manifesting with meningitis,
cranial neuritis, radiculoneuritis and other
symptoms often reported as Bannwarth syndrome
(1). Various encephalomyelitic forms of
the disease can also occur posing the tendency to
chronicity (2-4). The Czech Republic is an area
of borreliosis endemicity with an estimated incidence
of 61 cases per 100,000 inhabitants (5).
According to different sources at least 20% of
cases of borreliosis develop neurologic complications
(6). The high prevalence of borrelia antibodies
in the population (5-10%) indicates that
the risk of getting an infection is quite high (7).
However, only in one to four out of 100 tick
bites, symptoms consistent with the disease
occur (8). The diagnosis of the acute stage of
NB seems to be relatively easier when compared
with the potential chronic course of NB and
other chronic autoimmune diseases of the nervous
system.
Multiple sclerosis (MS) is a chronic inflammatory
demyelinating disease with polysymptomatic
clinical pattern and the most common cause of
neurologic disability in young adults. The prevalence
of MS is about 60 per 100,000 in the Czech
Republic. In spite of fast evolution of paraclinical
methods like magnetic resonance and electrophysiology,
MS diagnosis is still based on clinical
pattern and course, supported by cerebrospinal
fluid (CSF) analysis confirming inflammatory
origin of the disease.
Borrelia burgdorferi. The spirochetes may invade
different organs including the nervous system,
heart, joints and skin. Involvement of the
nervous system called neuroborreliosis (NB) is
an inflammatory disease manifesting with meningitis,
cranial neuritis, radiculoneuritis and other
symptoms often reported as Bannwarth syndrome
(1). Various encephalomyelitic forms of
the disease can also occur posing the tendency to
chronicity (2-4). The Czech Republic is an area
of borreliosis endemicity with an estimated incidence
of 61 cases per 100,000 inhabitants (5).
According to different sources at least 20% of
cases of borreliosis develop neurologic complications
(6). The high prevalence of borrelia antibodies
in the population (5-10%) indicates that
the risk of getting an infection is quite high (7).
However, only in one to four out of 100 tick
bites, symptoms consistent with the disease
occur (8). The diagnosis of the acute stage of
NB seems to be relatively easier when compared
with the potential chronic course of NB and
other chronic autoimmune diseases of the nervous
system.
Multiple sclerosis (MS) is a chronic inflammatory
demyelinating disease with polysymptomatic
clinical pattern and the most common cause of
neurologic disability in young adults. The prevalence
of MS is about 60 per 100,000 in the Czech
Republic. In spite of fast evolution of paraclinical
methods like magnetic resonance and electrophysiology,
MS diagnosis is still based on clinical
pattern and course, supported by cerebrospinal
fluid (CSF) analysis confirming inflammatory
origin of the disease.