comme c'est un sujet qui me tient a coeur puisque j'ai du interrompre l'une de mes grossesses à 5 mois (à cause de lyme..mais ça je l'ai su bien plus tard), voici un document qui est peut être déjà quelque part dans le forum (et dans ce cas, veuillez m'excuser pour la répétition)
aud
http://iai.asm.org/cgi/content/abstract/63/1/66
transmission foetale
aud, lyme depuis 15-20 ans, trés malade depuis sept 2003
Re: transmission foetale
http://www.ncbi.nlm.nih.gov/pubmed/1936 ... dinalpos=2
Deux articles hongrois récents:
Orv Hetil. 2009 Apr 19;150(16):725-32.
[Lyme borreliosis--experience of the last 25 years in Hungary]
[Article in Hungarian]
Lakos A.
Kullancsbetegségek Ambulanciája, Budapest, Visegrádi u. 14. 1132. alakos@t-online.hu
We recognized the first Hungarian Lyme patients just 25 years ago, in 1984. It was exactly 20 years ago, when we opened the Lyme Disease Outpatient Service at the Central (László) Hospital for Infectious Diseases. 15 years ago we established the financially independent Center for Tick-borne Diseases. The milestones of this work at the Center for Tick-borne Diseases are the description of a new tick-borne rickettsial illness (tick-borne lymphadenopathy), development of a Lyme immunoblot kit and an automated immunoblot reader. We described a simple and reliable method for detection of intrathecal borrelia antibody synthesis which is necessary for the diagnosis of neuroborreliosis. We also developed and routinely apply the comparative immunoblot assay for the evaluation of serological progression and/or regression, which can help the clinicians to decide whether a serological reaction is resulted from a previous healed or an active borrelia infection. We studied the pregnancy outcome of borrelia infected mothers and provided that untreated borrelia infection is associated with higher chance of adverse pregnancy outcome.
PMID: 19362925 [PubMed - indexed for MEDLINE]
----------------------------------------------------------------------------------------------------------------------
Maternal Lyme borreliosis and pregnancy outcome
International Journal of Infectious Diseases, 11/20/09
András Lakosa , Norbert Solymosib
Received 10 April 2009; received in revised form 29 May 2009; accepted 23 July 2009. published online 19 November 2009.
Summary
Background
There is disagreement regarding whether Lyme borreliosis is associated with adverse pregnancy outcome.
Methods
We performed a review of the data from 95 women with Lyme borreliosis during pregnancy, evaluated at the Center for Tick-borne Diseases, Budapest over the past 22 years.
Results
Treatment was administered parenterally to 66 (69.5%) women and orally to 19 (20%). Infection remained untreated in 10 (10.5%) pregnancies. Adverse outcomes were seen in 8/66 (12.1%) parentally treated women, 6/19 (31.6%) orally treated women, and 6/10 (60%) untreated women. In comparison to patients treated with antibiotics, untreated women had a significantly higher risk of adverse pregnancy outcome (odds ratio (OR) 7.61, p = 0.004). While mothers treated orally had an increased chance (OR 3.35) of having an adverse outcome compared to those treated parenterally, this difference was not statistically significant (p = 0.052). Erythema migrans did not resolve by the end of the first antibiotic course in 17 patients. Adverse pregnancy outcome was more frequent among these `slow responder' mothers (OR 2.69), but this was not statistically significant (p = 0.1425) . Loss of the pregnancy (n = 7) and cavernous hemangioma (n = 4) were the most prevalent adverse outcomes in our series. The other complications were heterogeneous.
Conclusion
Our results indicate that an untreated maternal Borrelia burgdorferi s.l. infection may be associated with an adverse outcome, although bacterial invasion of the fetus cannot be proven. It appears that a specific syndrome representing `congenital Lyme borreliosis' is unlikely.
Corresponding Editor: William Cameron, Ottawa, Canada
Keywords: Lyme disease, Borrelia burgdorferi s.l. Infection, Pregnancy outcome, Pregnancy loss
a The Center for Tick-borne Diseases, Visegrádi 14, Budapest, H-1132, Hungary
b Adaptation to Climate Change Research Group, HAS-BCU, Villányi út 29-43, Budapest, H-1118, Hungary
Corresponding author. Tel.: +36 30 9619134; fax: +36 1 3293898.
PII: S1201-9712(09)00331-2
doi:10.1016/j.ijid.2009.07.019
© 2009 International Society for Infectious Diseases. Published by Elsevier Inc. All rights reserved.
Deux articles hongrois récents:
Orv Hetil. 2009 Apr 19;150(16):725-32.
[Lyme borreliosis--experience of the last 25 years in Hungary]
[Article in Hungarian]
Lakos A.
Kullancsbetegségek Ambulanciája, Budapest, Visegrádi u. 14. 1132. alakos@t-online.hu
We recognized the first Hungarian Lyme patients just 25 years ago, in 1984. It was exactly 20 years ago, when we opened the Lyme Disease Outpatient Service at the Central (László) Hospital for Infectious Diseases. 15 years ago we established the financially independent Center for Tick-borne Diseases. The milestones of this work at the Center for Tick-borne Diseases are the description of a new tick-borne rickettsial illness (tick-borne lymphadenopathy), development of a Lyme immunoblot kit and an automated immunoblot reader. We described a simple and reliable method for detection of intrathecal borrelia antibody synthesis which is necessary for the diagnosis of neuroborreliosis. We also developed and routinely apply the comparative immunoblot assay for the evaluation of serological progression and/or regression, which can help the clinicians to decide whether a serological reaction is resulted from a previous healed or an active borrelia infection. We studied the pregnancy outcome of borrelia infected mothers and provided that untreated borrelia infection is associated with higher chance of adverse pregnancy outcome.
PMID: 19362925 [PubMed - indexed for MEDLINE]
----------------------------------------------------------------------------------------------------------------------
Maternal Lyme borreliosis and pregnancy outcome
International Journal of Infectious Diseases, 11/20/09
András Lakosa , Norbert Solymosib
Received 10 April 2009; received in revised form 29 May 2009; accepted 23 July 2009. published online 19 November 2009.
Summary
Background
There is disagreement regarding whether Lyme borreliosis is associated with adverse pregnancy outcome.
Methods
We performed a review of the data from 95 women with Lyme borreliosis during pregnancy, evaluated at the Center for Tick-borne Diseases, Budapest over the past 22 years.
Results
Treatment was administered parenterally to 66 (69.5%) women and orally to 19 (20%). Infection remained untreated in 10 (10.5%) pregnancies. Adverse outcomes were seen in 8/66 (12.1%) parentally treated women, 6/19 (31.6%) orally treated women, and 6/10 (60%) untreated women. In comparison to patients treated with antibiotics, untreated women had a significantly higher risk of adverse pregnancy outcome (odds ratio (OR) 7.61, p = 0.004). While mothers treated orally had an increased chance (OR 3.35) of having an adverse outcome compared to those treated parenterally, this difference was not statistically significant (p = 0.052). Erythema migrans did not resolve by the end of the first antibiotic course in 17 patients. Adverse pregnancy outcome was more frequent among these `slow responder' mothers (OR 2.69), but this was not statistically significant (p = 0.1425) . Loss of the pregnancy (n = 7) and cavernous hemangioma (n = 4) were the most prevalent adverse outcomes in our series. The other complications were heterogeneous.
Conclusion
Our results indicate that an untreated maternal Borrelia burgdorferi s.l. infection may be associated with an adverse outcome, although bacterial invasion of the fetus cannot be proven. It appears that a specific syndrome representing `congenital Lyme borreliosis' is unlikely.
Corresponding Editor: William Cameron, Ottawa, Canada
Keywords: Lyme disease, Borrelia burgdorferi s.l. Infection, Pregnancy outcome, Pregnancy loss
a The Center for Tick-borne Diseases, Visegrádi 14, Budapest, H-1132, Hungary
b Adaptation to Climate Change Research Group, HAS-BCU, Villányi út 29-43, Budapest, H-1118, Hungary
Corresponding author. Tel.: +36 30 9619134; fax: +36 1 3293898.
PII: S1201-9712(09)00331-2
doi:10.1016/j.ijid.2009.07.019
© 2009 International Society for Infectious Diseases. Published by Elsevier Inc. All rights reserved.
Re: transmission foetale
Si jai bien compris ce que je lis ici, le risque de fausse couche est eleve en phase aigue de lyme. En phase chronique il y a moins de risque de fausse couche.
le risque de le passer au foetus par contre est identique, parce que la grossesse accroît le risque de transmission en raison de son effet immunosuppresseur.
le risque de le passer au foetus par contre est identique, parce que la grossesse accroît le risque de transmission en raison de son effet immunosuppresseur.
Re: transmission foetale
http://www.infectiologie.com/UserFiles/ ... I-jean.pdf
Document de 2013 qui résume quelque peu la situation....il y en a plein d'autres!
Document de 2013 qui résume quelque peu la situation....il y en a plein d'autres!
Cordialement
Léa
Léa